Question : do i need to shutdown owa service to end users during the patching of desktops and Exchange server? Answer: When you patch CDO on the Exchange server, it will restart the store.exe process. But you do not need to do anything special for OWA
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Read the complete post at http://blogs.technet.com/dst2007/archive/2007/02/23/do-i-need-to-shutdown-owa-service-to-end-users-during-the-patching-of-desktops-and-exchange-server.aspx