As an aid to clearing up some of the confusion around supported Cluster configurations the Product Group posted a list of supported and unsupported configurations here http://blogs.technet.com/momteam/archive/2007/11/30/supported-cluster-configurations
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Read the complete post at http://blogs.technet.com/cliveeastwood/archive/2007/11/30/list-of-opsmgr-cluster-configurations-supported.aspx